Yuki’s earliest memory is of a snowy night in winter, when she was attacked by one vampire and was saved by another, Kaname Kuran. Ten years later, Yuki Cross, the adopted daughter of the headmaster of Cross Academy, has grown up and become a guardian for the school, with two purposes: To protect the Day class (humans) from the Night class (vampires)’s fangs and to protect the true identity of the Night class students from being discovered by the Day class students.

Kaname Kuran, Yuki’s savior, leads the group of Night class, with the help of Takuma Ichijo. But also at her side is Zero Kiryu, a childhood friend who was born into a family of vampire hunters and whose hatred for the vampires that destroyed everything he held dear, is now determined to kill them all and never trusts them. Through a cruel twist of fate, Zero becomes a vampire himself, having been bitten by a pureblood.